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Search for "in situ monitoring" in Full Text gives 7 result(s) in Beilstein Journal of Organic Chemistry.
Multi-faceted reactivity of N-fluorobenzenesulfonimide (NFSI) under mechanochemical conditions: fluorination, fluorodemethylation, sulfonylation, and amidation reactions
Beilstein J. Org. Chem. 2022, 18, 182–189, doi:10.3762/bjoc.18.20
- solution, the mechanochemical reactions were accomplished in the absence of solvents, in short reaction times, and in yields comparable to or higher than their solvent-based counterparts. Keywords: amidation; ball mill; fluorination; in situ monitoring; mechanochemistry; NFSI; Raman monitoring
Mechanochemistry of nucleosides, nucleotides and related materials
Beilstein J. Org. Chem. 2018, 14, 955–970, doi:10.3762/bjoc.14.81
- observations at a molecular scale [97] and from in situ monitoring of bulk-scale reactions [98]. The limited work relating to the chemical transformation of nucleoside and nucleotide substrates has been mainly focussed upon exploiting the (lack of) solvent requirements. This can allow access to unprecedented
Solvent-free copper-catalyzed click chemistry for the synthesis of N-heterocyclic hybrids based on quinoline and 1,2,3-triazole
Beilstein J. Org. Chem. 2017, 13, 2352–2363, doi:10.3762/bjoc.13.232
- the reaction and generation of highly luminescent compounds which hindered in situ monitoring by Raman spectroscopy. However, in situ monitoring of the milling processes was enabled by using Cu(0) catalysts in the form of brass milling media which offered a direct insight into the reaction pathway of
The effect of milling frequency on a mechanochemical organic reaction monitored by in situ Raman spectroscopy
Beilstein J. Org. Chem. 2017, 13, 2160–2168, doi:10.3762/bjoc.13.216
- ], which have all revealed a non-linear relationship between milling frequency and reaction conversion. Results and Discussion In situ monitoring of the model condensation reaction A preliminary investigation of the model condensation reaction was conducted by milling of o-phenylenediamine (108 mg, 1.0
- starting materials and the product exhibit characteristic signals, and the PMMA spectrum is featureless (Figure 2). Fitting the dataset A principal challenge associated with in situ monitoring of a milling reaction is the variation of the amount of sample in the beam due to the motion of the milling
- with the in situ Raman spectroscopy data. Averaging the triplicate measurements of the time-dependent variation of product spectral contribution for each frequency (Figure 4) reveals remarkable sensitivity of the reaction rate on small changes in milling frequency. The in situ monitoring data indicates
Mechanochemical synthesis of small organic molecules
Beilstein J. Org. Chem. 2017, 13, 1907–1931, doi:10.3762/bjoc.13.186
- under the LAG (liquid-assisted grinding) synthesis (Scheme 58) [190]. Initially, in situ monitoring of mechanochemical thiocarbamoylation suggests the formation of reactive intermediate which gradually disappears with the formation of thiocarbamoylated product. Furthermore isolation and spectroscopic
NMR reaction monitoring in flow synthesis
Beilstein J. Org. Chem. 2017, 13, 285–300, doi:10.3762/bjoc.13.31
- with a line of <1 Hz in ethanol. As a proof-of-concept, the integrated flow system (microreactor-stripline NMR chip) was tested in the acylation of benzyl alcohol with acetyl chloride (Figure 7) using DIPEA as the base. The kinetics were studied by in situ monitoring and it was found that 70
Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
Beilstein J. Org. Chem. 2012, 8, 300–307, doi:10.3762/bjoc.8.32
- reaction, the product formation ( = 1495 cm−1) and substrate consumption ( = 1479 cm−1) can be determined in real time. Analysis of the spectra provided us with an optimal temperature of 60 °C for this reaction. In general the IR-flow-cell technology is a good tool for in situ monitoring and provides a
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